ABSTRACT The high global burden of cryptococcosis has made development of a protective vaccine a public health priority.We previously demonstrated that a vaccine composed of recombinant Cryptococcus neoformans chitin deacetylase 2 (Cda2) delivered in glucan particles (GPs) protects BALB/c and C57BL/6 mice from an otherwise lethal challenge with a h
The Pictet-Spengler reaction (P-S) is one of Saucepan Set the most direct, efficient, and variable synthetic method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), and polyheterocyclic frameworks.In the lustro (five-year period) following its centenary birthday, the P
Abstract Background Oxygen supplementation is commonly given to the patients with severe pneumonia including Legionella disease.Recent data suggested that apoptosis may play console cover top an important role, not only in the pathogenesis of Legionella pneumonia, but also in oxygen-induced tissue damage.In the present study, the lethal sensitivity